boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]- - Names and Identifiers
Name | [4-(2,2,2-trifluoroethoxy)phenyl]boronic acid
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Synonyms | (4-(2,2,2-Trifluoroethoxy) 4-(2,2,2-Trifluoroethoxy)phenylboronicacid 4-(2,2,2-trifluoroethoxy)phenyboronic acid 4-(2,2,2-TRIFLUOROETHOXY)PHENYLBORONIC ACID 4-(2,2,2-Trifluoroethoxy)benzeneboronic acid [4-(2,2,2-trifluoroethoxy)phenyl]boronic acid boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]- Boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]- 4-(2,2,2-Trifluoroethoxy)benzeneboronic acid, [4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid
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CAS | 886536-37-4
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InChI | InChI=1/C8H8BF3O3/c10-8(11,12)5-15-7-3-1-6(2-4-7)9(13)14/h1-4,13-14H,5H2 |
boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]- - Physico-chemical Properties
Molecular Formula | C8H8BF3O3
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Molar Mass | 219.95 |
Density | 1.35±0.1 g/cm3(Predicted) |
Melting Point | 191-194℃ |
Boling Point | 297.1±50.0 °C(Predicted) |
Flash Point | 133.5°C |
Vapor Presure | 0.000618mmHg at 25°C |
pKa | 8.58±0.16(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.463 |
boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]- - Risk and Safety
Hazard Symbols | Xi - Irritant
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Hazard Note | Irritant |
boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]- - Introduction
[4-(2,2,2-trifluoroethoxy)phenyl]boronic acid is an organic compound with the chemical formula C8H8BF3O3. It exists in the form of a white solid.
Its properties are as follows:
1. Melting point: about 120-125°C;
2. Solubility: Soluble in some organic solvents, such as chloroform, ether, etc;
3. Stability: relatively stable at room temperature, but sensitive to air and moisture.
Its main use is as a ligand and reagent in organic synthesis. It can form complexes with alkali metals (e. g., palladium, platinum, etc.) as catalysts for organic reactions, such as coupling reactions, C- H bond activation, reduction reactions, oxidation reactions, etc. In addition, it is also commonly used in drug synthesis and materials science.
The method for preparing [4-(2,2,2-trifluoroethoxy)phenyl]boronic acid is generally to react phenyl boronic acid with p-trifluoroethanol ester. The reaction is typically carried out at a relatively low temperature and under an inert atmosphere, such as a nitrogen blanket. After the reaction, the target product is obtained by distillation or the like.
Regarding safety information, as chemicals are involved, the following should be noted when using:
1. The compound may be irritating and corrosive to the eyes, skin and respiratory system. Wear appropriate personal protective equipment, such as safety glasses, lab gloves and breathing masks;
2. avoid inhalation, contact with skin and intake, avoid contact with oxidants, strong acids and other dangerous substances;
3. The treatment process should be carried out in a well-ventilated place to avoid harmful gases such as dust and aerosols;
4. storage should avoid direct sunlight, keep the container closed, dry and away from heat.
Please read the relevant safety instructions and operating instructions carefully before use, and strictly follow the correct laboratory operating procedures for operation and handling.
Last Update:2024-04-09 21:04:16